255 IL-1 REDUCES ANTIOXIDANT PROTECTION IN CARTILAGE
نویسندگان
چکیده
منابع مشابه
Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme Expression
OBJECTIVE: Exposure of articular cartilage to interleukin-1 (IL-1) results in increased synthesis of matrix degrading enzymes. Previously mechanical load applied together with IL-1 stimulation was found to reduce aggrecan cleavage by ADAMTS-4 and 5 and MMP-1, -3, -9, and -13 and reduce proteoglycan loss from the extracellular matrix. To further delineate the inhibition mechanism the gene expres...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2010
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(10)60282-8